Hirsutanol A Induces Apoptosis and Autophagy via Reactive Oxygen Species Accumulation in Breast Cancer MCF-7 Cells
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概要
- 論文の詳細を見る
Hirsutanol A is a novel sesquiterpene compound purified from the marine fungus <I>Chondrostereum</I> sp in the coral <I>Sarcophyton tortuosum</I>. Our previous studies had demonstrated that hirsutanol A exerted potent cytotoxic effect in many kinds of cancer cell lines. Here, the anticancer molecular mechanisms of hirsutanol A were investigated in breast cancer MCF-7 cells. The results showed that hirsutanol A could inhibit cell proliferation, elevate reactive oxygen species (ROS) level, and induce apoptosis and autophagy. Co-treatment with the potent antioxidant agent <I>N</I>-acetyl-L-cysteine could effectively reverse the effect of enhanced ROS production, which in turn, reduces growth inhibition, apoptosis, and autophagy mediated by hirsutanol A. In addition, blocking autophagy by bafilomycin A1 or Atg7-siRNA could synergistically enhance the antiproliferative effect and apoptosis induced by hirsutanol A. These data suggested that hirsutanol A could induce apoptosis and autophagy via accumulation of ROS and co-treatment with an autophagy inhibitor could sensitize MCF-7 cells to hirsutanol A.
- 公益社団法人 日本薬理学会の論文
著者
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Zhu Xiao-feng
State Key Laboratory Of Oncology In South China
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FENG Gong-Kan
State Key Laboratory of Oncology in South China
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DENG Rong
State Key Laboratory of Oncology in South China
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LI Dan-Dan
State Key Laboratory of Oncology in South China
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Yang Fen
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, China
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Chen Wen-Dan
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, China
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Wu Ke-Wei
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, China
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Li Hou-Jin
Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, China
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Chen Wen-dan
State Key Laboratory Of Oncology In South China Cancer Center Sun Yat-sen University
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Wu Ke-wei
State Key Laboratory Of Oncology In South China Cancer Center Sun Yat-sen University
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Li Hou-jin
Institute Of Organic Chemistry School Of Chemistry And Chemical Engineering Sun Yat-sen University
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Li Dan-Dan
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, China
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- Hirsutanol A Induces Apoptosis and Autophagy via Reactive Oxygen Species Accumulation in Breast Cancer MCF-7 Cells
- Hirsutanol A Induces Apoptosis and Autophagy via Reactive Oxygen Species Accumulation in Breast Cancer MCF-7 Cells