Evaluation of Formalin-Induced Pain Behavior and Glutamate Release in the Spinal Dorsal Horn Using In Vivo Microdialysis in Conscious Rats

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概要

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• Measurement of neurotransmitters in the spinal dorsal horn in conscious animals remains a technical challenge. Here we applied concentric microdialysis to measure formalin-induced glutamate (Glu) release in the ipsilateral dorsal horn in conscious, freely-moving rats. Hind paw formalin injection induced flinching nociceptive behaviors accompanied by increased Glu in the dorsal horn (maximum = 294%). Both flinching and Glu increase were prevented by morphine (3 mg/kg, s.c.). Accordingly, concentric microdialysis is a sensitive technique for studying neurochemical modulation induced by pain and analgesics in the spinal dorsal horn of awake rats. Measurement of Glu provides information on modulation of excitatory signals.

• 公益社団法人 日本薬理学会の論文

著者

• Zamanillo Daniel

  Department Of Pharmacology Drug Discovery And Preclinical Development

• Vela Jose

  Department Of Pharmacology Drug Discovery And Preclinical Development

• Vidal-Torres Alba

  Department of Pharmacology, Drug Discovery and Preclinical Development, ESTEVE, Spain

• Carceller Alicia

  Department of Pharmacology, Drug Discovery and Preclinical Development, ESTEVE, Spain

• Merlos Manuel

  Department of Pharmacology, Drug Discovery and Preclinical Development, ESTEVE, Spain

• Fernández-Pastor Begoña

  Department of Pharmacology, Drug Discovery and Preclinical Development, ESTEVE, Spain

関連論文

• Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT7 Receptors
• Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT_7 Receptors
• Evaluation of Formalin-Induced Pain Behavior and Glutamate Release in the Spinal Dorsal Horn Using In Vivo Microdialysis in Conscious Rats
• Evaluation of Formalin-Induced Pain Behavior and Glutamate Release in the Spinal Dorsal Horn Using In Vivo Microdialysis in Conscious Rats

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