Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates
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概要
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Serotonin (5-HT) 1A receptors exist in high and low affinity states. Agonist ligands bind preferentially to the high affinity state receptors, providing a more functionally relevant measure than antagonist binding. We now report comparison of 5-HT<SUB>1A</SUB> binding in vivo using both [<SUP>11</SUP>C]CUMI-101 (agonist) and [<SUP>11</SUP>C]WAY100635 (antagonist) in nonhuman primates. PET studies show that both tracers bind to known 5-HT<SUB>1A</SUB> receptor (5-HT<SUB>1A</SUB>R)-rich regions of baboon brain. The binding (BP<SUB>F</SUB>) of [<SUP>11</SUP>C]CUMI-101 was lower on an average of 55% across the regions of interest (ROIs) compared to [<SUP>11</SUP>C]WAY100635. This ratio is consistent with the in vitro binding data of agonist and antagonist 5-HT<SUB>1A</SUB>R ligands previously reported.
著者
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Mann J.
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA
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Kumar J.S.
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA
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Milak Matthew
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA
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Majo Vattoly
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA
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Prabhakaran Jaya
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA
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Mali Pratap
New York State Psychiatric Institute, USA
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Savenkova Lyudmila
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA
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Parsey Ramin
Department of Psychiatry and Behavioral Medicine, Stony Brook University, USA
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PRABHAKARAN Jaya
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons
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MANN J.
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University College of Physicians and Surgeons
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PARSEY Ramin
Department of Psychiatry and Behavioral Medicine, Stony Brook University
関連論文
- Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates
- Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates