Influence of the Injection Site on the Pharmacokinetics of Cefquinome Following Intramuscular Injection in Piglets

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The aim of the present study was to investigate the influence of different injection sites, i.e., the neck area and thigh muscle, on pharmacokinetcs of cefquinome in piglets following intramuscular (i.m.) injection. Cross-bred (Landrace × Duroc × Yorkshire) piglets were administered cefquinome (2 mg/kg body weight) via intravenous injection and intramuscular injection of the same dose into the neck area or thigh. The mean maximum concentration (Cmax) of cefquinome following i.m. injection into the neck or thigh area were 4.62 ± 0.31 μg/ml at 0.38 ± 0.14 hr and 4.39 ± 0.53 μg/ml at 0.42 ± 0.13 hr, respectively (P<0.05). The absolute bioavailabilities (F) of cefquinome after i.m. injection into the neck or thigh area were 103.04 ± 13.01 and 97.56 ± 16.14%, respectively (P<0.05). There were no differences noted between two different injection sites for the pharmacokinetic properties of cefqruimone after i.m. injection in piglets. Further studies will be needed to determine the incidence or severity of injection site reactions following repeated administration of cefquinome into both injection sites