Protection of Mice against X-ray Injuries by the Post-irradiation Administration of Inosine-5'-monophosphate

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概要

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• The aim of the present study was to investigate the radiation modulating properties of inosine-5'-monophosphate (IMP). Mice injected introperitoneally (i.p.) with IMP 15 minutes after irradiation with a lethal irradiation dose of 7 Gy have better survival rates comparative to irradiated mice non treated with IMP. The dose reduction factor of the IMP is 1.22. Using a hematologdical test we demonstrated that administration of IMP alleviates the symptoms of radiation-induced leukopenia and thrombocytopenia. The DNA damage in bone marrow and thymus cells of irradiated mice was measured by flow cytofluorometry and micronucleus test (MN-test). The tests show that i.p. administration of IMP to irradiated animals leads to a significant reduction of the DNA damage level. In this paper we show that IMP substantially modulates the damaging effects of ionizing radiation protecting irradiated mice and it is a promising agent for a treatment of leukopenia.

• Journal of Radiation Research 編集委員会の論文

著者

• GUDKOV Sergey

  Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

• ASADULLINA Nelli

  Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

• USACHEVA Anna

  Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

関連論文

• Protection of Mice against X-ray Injuries by the Post-irradiation Administration of Inosine-5'-monophosphate

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