Endothelial Nitric Oxide-Dependent Vasorelaxant Effect of Isotirumalin, a Dihydroflavonol from Derris urucu, on the Rat Aorta

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概要

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• The present work aimed to investigate the vasorelaxant effect of isotirumalin, a dihydroflavonol isolated from Derris urucu (Leguminosae). The vasorelaxant effect of isotirumalin was investigated in the rat aorta, in the presence and in the absence of a functional endothelium. The production of nitric oxide (NO) induced by isotirumalin was measured simultaneously with its vasorelaxation using carbon microsensors. In endothelium-intact aortic rings, isotirumalin induced a concentration-dependent vasodilator effect the concentration required to produce 30% of relaxation (pIC30=4.84±0.24) that was abolished in endothelium-denuded aortic rings or in the presence of Nω-nitro-L-arginine-methyl-ester (L-NAME; 300 μM). In addition, isotirumalin (100 μM) induced a simultaneous and significant increase on NO production, which was blunted in the presence of L-NAME. The present results demonstrate that isotirumalin is a vasodilator in the rat aorta and act by a mechanism dependent on the presence of a functional endothelium and on NO production.

著者

• Da Silva

  Faculdade De Ciencias Farmaceuticas Universidade Sao Francisco

• Mendes Liliane

  Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais

• Capettini Luciano

  Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais

• Arruda Mara

  Faculdade de Química, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará

• Lemos Virgínia

  Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais

• Lôbo Lívia

  Faculdade de Química, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará

• Côrtes Steyner

  Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais

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• Endothelial Nitric Oxide-Dependent Vasorelaxant Effect of Isotirumalin, a Dihydroflavonol from Derris urucu, on the Rat Aorta

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