Leishmanicidal Activity of Two Naphthoquinones against Leishmania donovani

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概要

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• Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.

• 公益社団法人　日本薬学会の論文

著者

• Satoskar Abhay

  Department Of Microbiology Ohio State University

• Lezama-davila Claudio

  Department Of Microbiology Ohio State University

• Isaac-Márquez Angelica

  Centro de Investigaciones en Enfermedades Tropicales, Universidad Autónoma de Campeche

• Kapadia Govind

  Department of Pharmaceutical Sciences, School of Pharmacy, Howard University

• Owens Katherine

  Department of Molecular Microbiology, Washington University School of Medicine

• Oghumu Steve

  Department of Pathology, The Wexner Medical Centre, The Ohio State University

• Beverley Stephen

  Department of Molecular Microbiology, Washington University School of Medicine

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• Leishmanicidal Activity of Two Naphthoquinones against Leishmania donovani

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