Anti-arthritic Effect of Eugenol on Collagen-Induced Arthritis Experimental Model

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概要

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• This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in the hind paws. Treatment with eugenol starting at the onset of arthritis (day 25) ameliorated these clinical signs of CIA. Furthermore, eugenol inhibited mononuclear cell infiltration into the knee joints of arthritic mice and also lowered the levels of cytokines (tumor necrosis factor (TNF)-α, interferon (IFN)-γ and tumor growth factor (TGF)-β) within the ankle joints. Eugenol treatment did not affect the in vitro cell viability as assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Therefore, eugenol ameliorates experimental arthritis and could be useful as a beneficial supplement in treating human arthritis.

著者

• Barbosa Carmem

  Department of Pharmacology and Therapeutics, State University of Maringá

• Dalalio Marcia

  Department of Clinical Analysis, State University of Maringá

• Lemos Henrique

  Immunotherapy Center, Georgia Health Sciences University

• Cuman Roberto

  Department of Pharmacology and Therapeutics, State University of Maringá

• Grespan Renata

  Department of Pharmacology and Therapeutics, State University of Maringá

• Bersani-Amado Ciomar

  Department of Pharmacology and Therapeutics, State University of Maringá

• Paludo Marcia

  Department of Pharmacology and Therapeutics, State University of Maringá

関連論文

• Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro
• Anti-arthritic Effect of Eugenol on Collagen-Induced Arthritis Experimental Model

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