遷移金属触媒を用いないヘテロ芳香族化合物のクロスカップリング反応の開発
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概要
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Biaryl compounds are versatile building blocks in the synthesis of natural products, pharmaceuticals, agricultural chemicals and π-conjugated organic materials. This review describes a recent progress for the biaryl cross-coupling reaction of heteroaromatic compounds using hypervalent iodine reagent. Our novel biaryl coupling reaction is a unique method for constructing various heteroaromatic biaryls without use of transition metal catalysts. From mechanistic point of view, the coupling reaction was realized through stable iodine intermediate generated from heteroaroamatic compound and iodine (III) reagent.
- 公益社団法人 日本薬学会の論文