Serum and Dietary Magnesium and Incidence of Atrial Fibrillation in Whites and in African Americans

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概要

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• Background: Low serum magnesium (Mg) has been associated with an increased risk of cardiovascular disease (CVD), including ventricular arrhythmias, but the association between serum or dietary Mg and atrial fibrillation (AF) has not been investigated. Methods and Results: A total of 14,290 men and women (75% white; 53% female; mean age, 54 years) free of AF at baseline participating in the Atherosclerosis Risk in Communities study in the United States, were studied. Incident AF cases through 2009 were ascertained from electrocardiograms, hospital discharge codes, and death certificates. Multivariate Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for AF associated with serum and dietary Mg quintiles. Over a median follow-up time of 20.6 years, 1,755 incident AF cases were identified. In multivariate models, lower serum Mg was associated with higher AF risk: compared to individuals in the middle quintile (≥0.80–0.83mmol/L), the HR (95% CI) of AF in quintiles 1, 2, 4, and 5 were 1.34 (1.16–1.54), 0.99 (0.85–1.16), 1.04 (0.90–1.22), and 1.06 (0.91–1.23), respectively. There was no evidence of significant interactions between serum Mg and sex or race. No association between dietary Mg and AF risk was observed. Conclusions: Lower serum Mg was associated with a higher AF risk, and this association was not different between whites and African Americans. Dietary Mg was not associated with AF risk.

著者

• Alonso Alvaro

  Division Of Epidemiology And Community Health School Of Public Health University Of Minnesota

• Soliman Elsayed

  Epidemiological Cardiology Research Center (epicare) Department Of Epidemiology And Prevention Wake

• Agarwal Sunil

  Department of Epidemiology, University of North Carolina at Chapel Hill

• Misialek Jeffrey

  Division of Epidemiology and Community Health, School of Public Health, University of Minnesota

• Lopez Faye

  Division of Epidemiology and Community Health, School of Public Health, University of Minnesota

• Lutsey Pamela

  Division of Epidemiology and Community Health, School of Public Health, University of Minnesota

• Huxley Rachel

  Division of Epidemiology and Community Health, School of Public Health, University of Minnesota

• Peacock James

  Center for Health Promotion, Health Promotion and Chronic Disease Division, Minnesota Department of Health, St. Paul

• Chen Lin

  Cardiovascular Division, University of Minnesota Medical School

• Soliman Elsayed

  Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, and Department of Internal Medicine (Cardiology Section), Wake Forest School of Medicine

• PEACOCK James

  Center for Health Promotion, Health Promotion and Chronic Disease Division, Minnesota Department of Health

関連論文

• Diet and Risk of Atrial Fibrillation : Epidemiologic and Clinical Evidence
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• Serum and Dietary Magnesium and Incidence of Atrial Fibrillation in Whites and in African Americans
• Serum and Dietary Magnesium and Incidence of Atrial Fibrillation in Whites and in African Americans : Atherosclerosis Risk in Communities (ARIC) Study

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