Structure-Activity Relationship Studies of Novel Glycosphingolipids That Stimulate Natural Killer T-Cells

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概要

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• KRN7000, an anticancer drug candidate developed by Kirin Brewery Co. in 1995, is an α-galactosyl ceramide. It is a ligand making a complex with CD1d protein, and it stimulates invariant natural killer T (NKT) cells, which are one of the lineages of immunocytes. NKT cells activated by recognition of the CD1d/KRN7000 complex with its invariant T-cell receptor (TCR) can induce both protective and regulatory immune responses. To determine the recognition and activation mechanisms of NKT cells and to develop drug candidates more effective than KRN7000, a large number of analogs of KRN7000 have been synthesized. Some of them show potent bioactivities and have the potential of being utilized as therapeutic agents. In this review, structure-activity relationship studies of novel glycolipids which stimulate NKT cells efficiently are summarized.

• Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文

著者

• Tashiro Takuya

  Glycosphingolipid Synthesis Group Laboratory For Immune Regulation Research Center For Allerey And Immunology Riken

関連論文

• KRN7000の開発から15年-ナチュラルキラーT細胞を活性化する新規スフィンゴ糖脂質の構造活性相関研究
• Syntheses of 2-Isopropyl-4, 5-dihydrothiazole and 6-Hydroxy-6-methyl-3-heptanone, Pheromone Components of the Male Mouse, Mus musculus
• Structure-Activity Relationship Studies of Novel Glycosphingolipids That Stimulate Natural Killer T-Cells
• Structure-Activity Relationship Studies of Novel Glycosphingolipids That Stimulate Natural Killer T-Cells
• Synthesis of Sphingolipids with an ω-Esterified Long Acyl Chain, Ceramide Components of the Human Epidermis

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