Synthesis and Antiproliferative Activity of Novel α-Aminophosphonates

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概要

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• A novel series of carbazole-based α-aminophosphonates were synthesized by three component coupling of 6-bromo-9-ethyl-9H-carbazole-3-carbaldehyde, amine and diethyl phosphite using polyethylene glycol (PEG-400) as a green reaction media. The antiproliferative activity of these molecules was evaluated against three cancer cell lines. Of these, compounds 4c, 4e and 4m were found to exhibit good antiproliferative activity against three cancer cells, A549, MCF-7, and NCI-N87.

著者

• Anil Kumar

  Department of Chemistry, Sri Venkateswara University

• Lee Kap

  Department Of Chemistry Dongguk University

• Park Yong-Ki

  Department of Herbology, Dongguk University

• Duk Lee

  Department of Nanomaterial Chemistry, Dongguk University

• Mungara Anil

  Department of Nanomaterial Chemistry, Dongguk University

• Lee Kap

  Department of Nanomaterial Chemistry, Dongguk University

• PARK Yong-Ki

  Department of Herbology, College of Oriental Medicine, Dongguk University

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