Total Synthesis of Hydroxy-α- and Hydroxy-β-sanshool Using Suzuki–Miyaura Coupling

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概要

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• Here, we describe the first total synthesis of hydroxyl-α- and hydroxyl-β-sanshool, which involves Suzuki–Miyaura coupling (SMC). Hydroxy-α-sanshool (1) was synthesized by SMC of bromoalkyne 4 with boronate 3 followed by (Z)-selective reduction of the triple bond in the coupling product. Hydroxy-β-sanshool (2) was synthesized by regio- and (E)-selective conversion of 4 to iodoalkene 11 followed by SMC with 3.

著者

• Aoki Katsuyuki

  Kampo Formulations Development Center, Tsumura & Co.

• Igarashi Yasushi

  Kampo Formulations Development Center, Tsumura & Co.

• Nishimura Hiroaki

  Kampo Formulations Development Center, Tsumura & Co.

• Morishita Isao

  Kampo Formulations Development Center, Tsumura & Co.

• Usui Kimitoshi

  Kampo Formulations Development Center, Tsumura & Co.

• Morishita Isao

  Kampo Formulations Development Center, Tsumura & Co.

関連論文

• Total Synthesis of Hydroxy-α- and Hydroxy-β-sanshool Using Suzuki–Miyaura Coupling

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