Green Synthesis and Bioactivity of 2-Amino-4H-chromen-4-yl-phosphonates

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概要

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• A simple and efficient one pot synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives has been accomplished by the condensation of salicylaldehyde, malononitrile/ethylcyanoacetate and triethyl phosphite/trimethyl phosphite in the presence of molecular iodine as catalyst in water at room temperature. All the reactions were very clean and the products were obtained in very good to excellent yields. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.

• 公益社団法人　日本薬学会の論文

著者

• Reddy Cirandur

  Department Of Chemistry Biochemistry S.v. University

• Nayak Sandip

  Bio-organic Div. Barc

• Rajasekhar Mekala

  Department of Chemistry, Sri Venkateswara University

• Maheswara Rao

  Department of Chemistry, Sri Venkateswara University

• Sundar Chereddy

  Department of Chemistry, Sri Venkateswara University

• Reddy Nemallapudi

  Department of Chemistry, Sri Venkateswara University

• Nayak Sandip

  Bio-Organic Division, Bhabha Atomic Research Centre (BARC)

• Rao Kunda

  Department of Chemistry, Sri Venkateswara University

関連論文

• Green Synthesis and Bioactivity of 2-Amino-4H-chromen-4-yl-phosphonates
• Facile Synthesis, Antioxidant and Antimicrobial Activity of Amino Methylene Bisphosphonates

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