Synthesis of Some Novel Thiocyanotopurine Derivatives and Investigation of Their Antimicrobial Activity and DNA Interactions
スポンサーリンク
概要
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A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.
著者
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Dişli Ali
Department of Chemistry, Gazi University
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Celik Gulay
Department of Chemistry, Gazi University
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Disli Ali
Department of Chemistry, Gazi University
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Oner Yagmur
Department of Biology, Gazi University
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Açık Leyla
Department of Biology, Gazi University