Synthesis and Anti-tumor Activities of Novel Oxazinyl Isoflavonoids

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概要

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• The design, synthesis and biological evaluation of a novel series of oxazinyl isoflavonoids is described. Several analogs were shown to exhibit growth inhibitory effects against SKOV-3, DU-145 and HL-60 human colon cancer cell lines with IC50 values in the micromolar range. The cellular potency of compounds 7e and 12h were found to have greater in vitro inhibitory activities than phenoxodiol, the parental compound currently in late-stage clinical trials for the treatment of cancer. The results shown are suitable for further lead optimization.

• 公益社団法人　日本薬学会の論文

著者

• Wang Dun

  College of Pharmacential Engineering, Shenyang Pharmaceutical University

• Hou Like

  College of Pharmacential Engineering, Shenyang Pharmaceutical University

• Wu Lirong

  College of Pharmacential Engineering, Shenyang Pharmaceutical University

• Yu Xin

  Medical & Regulatory Affairs Department, Fresenisu Kabi (China) Co., Ltd. BD

• Yu Xin

  Medical & Regulatory Affairs Department, Fresenisu Kabi (China) Co., Ltd. BD

関連論文

• Synthesis and Anti-tumor Activities of Novel Oxazinyl Isoflavonoids

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