Synthesis and Structure of the β-Carboline Derivatives and Their Binding Intensity with Cyclin-Dependent Kinase 2

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概要

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• Series of 3-substituted of 6-aminosulfonyl-β-carbolines were designed and synthesized. In addition, the binding mode of these β-carboline derivatives with cyclin-dependent kinase 2 (CDK2) was studied by means of fluorescence measurements and molecular docking calculation. The results showed that replacement of 3-cyclohexylmethoxy group will increase the hydrophobic binding interaction with the deep hydrophobic pocket of CDK2 correlate to the higher binding intensity.

著者

• Lu Tao

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Lu Yi

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Tang Yimin

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Wang Yue

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Jin Qiaomei

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Lin Guowu

  Department of Structural Biology, University of Pittsburgh School of Medicine

• Yang Taotao

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Wang Zhanwei

  State Key Laboratory of Natural Medicines, China Pharmaceutical University

• Liu Lifang

  Laboratory of Molecular Design and Drug Discovery, College of Basic Science, China Pharmaceutical University

関連論文

• Synthesis and Structure of the β-Carboline Derivatives and Their Binding Intensity with Cyclin-Dependent Kinase 2
• Novel 1H-Pyrazole-3-Carboxamide Derivatives: Synthesis, Anticancer Evaluation and Identification of Their DNA-binding Interaction

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