An Improved Method for Synthesis of 4,4-Dimethylpyrazolone and Application to Dihydropyridazinone Ring Formation

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概要

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• An improved method for 4,4-dimethylpyrazolone synthesis with t-butylcarbazate was described. The applicability of this method to dihydropyridazinone formation was demonstrated. This method is useful for suppressing the side reaction caused by the high nucleophilicity of hydrazine.

• 公益社団法人　日本薬学会の論文

著者

• Ochiai Koji

  Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd.

• Kojima Akihiko

  Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd.

• Kohno Yasushi

  Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd.

関連論文

• An Improved Method for Synthesis of 4,4-Dimethylpyrazolone and Application to Dihydropyridazinone Ring Formation

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