Biotransformation of Ursolic Acid by an Endophytic Fungus from Medicinal Plant Huperzia serrata
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概要
- 論文の詳細を見る
Endophytic fungi were used not only for their producing bioactive products but also for their ability to transform natural compounds. An endophytic fungus, isolated from medicinal plant Huperzia serrata, was identified as Umbelopsis isabellina based on the internal transcribed spacer of ribosomal DNA (rDNA-ITS) region. It was used to transform ursolic acid (1), a pentacyclic triterpene. Incubation of ursolic acid with U. isabellina afforded three products, 3β-hydroxy-urs-11-en-28,13-lactone (2), 3β,7β-dihydroxy-urs-11-en-28,13-lactone (3), 1β,3β-dihydroxy-urs-11-en-28,13-lactone (4). Although product 2 was a known compound, it was first obtained by microbial transformation. Products 3 and 4 were new compounds. The structural elucidation of the three compounds was achieved mainly by the 1D- and 2D-NMR, MS, IR data. The endophytic fungus U. isabellina can hydroxyate the C12–C13 double bond at position 13 of ursolic acid 1 and form a five-member lactone effectively. In the meantime, this fungus can also introduce the hydroxyl group at C-1 or C-7 of ursolic acid 1.
- 公益社団法人 日本薬学会の論文
著者
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Cui Jin-long
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical
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Yang Jun-shan
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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Fu Shao-bin
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College
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Feng Xu
Navy Medical Research Institute, China
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Sun Di-an
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College
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Cui Jin-long
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College
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