精神分裂病の遺伝学的異種性の知見補遺--気管支喘息の多発した家族集積性の高い非定型精神病の1家系について
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概要
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Long a topic of discussion, the rather heterogenous clinical types of schizophrenia are studied here on a case by case basis in view of symptoms and clinical course. At present, the so-called"atypical psychosis"with periodicity and good prognosis has been observed and is reported. The author has studied one family's history which corresponded to atypical psychosis, showing the hereditary model of autosomal dominant and a feature of multiple incidence of bronchial asthma at Karasuyama Mental Hospital affiliated with Showa University. This study is intended to clarify the hereditary proclivity toward atypical psychosis with symptoms identical to"disease entities"among the cases of schizophrenia judged as hereditarly heterogenous, with reference to a survey from the viewpoint of internal medicine to treat physical ailments such as bronchial asthma. The study of this specific family's history having closer relationship genetically strongly suggests a hereditary dependence and, also, it positively endorses Mitsuda's study rerognizing the presence of hereditary heterogeneity among schizophrenia and, further, it strongly supports Inoue's study which drew a similar conclusion in a study of monozygotic twins. The advancement of somatopathological studies such as this will certainly become the genesis for a resolution of the problem of nosological proclivities toward atypical psychosis and will be the basis for reconstruction of nosological classifications of endogenous psychosis.
- 昭和大学・昭和医学会の論文