小児期各種疾患における銅・亜鉛代謝について--とくにMCLSを中心として
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概要
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Copper and zinc metabolism of healthy children and in various types of diseased children, especially acute febrile mucocutaneous lymphnode syndrome (MCLS), was investigated. During acute stage of MCLS serum copper, concentration increased, while serum zinc concentration decreased, and normalized gradually during convalescent stage. It seems that this hypercupremia and hypozincemia during acute stage of MCLS are not due to the effect of environmental factors. The cases of abnormal course of MCLS, associated with coronary aneurysm, recrudescence and thrombocytopenia, showed higher concentration of serum copper and lower concentration of serum zinc than ordinary cases of MCLS. So it seems to be necessary to examine serum copper and zine concentration continuously as the indicator of heart involvement. During acute stage of bacterial infection, serum copper concentration increased, but purulent meningitis showed only mild increase in serum copper concentration. In general, viral infection did not show remarkable change in serum copper level, except in infectious mononucleosis, measles and exanthema subitum, which showed high concentration of serum copper during eruption stage. Serum copper concentration were also high in leukemia and malignant abdominal tumor, but brain tumor was within normal range of serum copper concentration. On the other hand, serum zinc level showed a slightly high level in acute upper respiratory infection, acute pneumonia and so on, but nephrotic syndrome showed a remarkably low concentration of serum zinc.
- 学校法人 昭和大学・昭和医学会の論文