針鎮痛求心路の誘発電位から検索した針鎮痛発現の経穴の性質
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概要
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The region of acupuncture points to cause acupuncture analgesia (AA) was investigated by evoked potential recorded from the dorsal periaqueduct central gray (d-PAG) by acupuncture stimulation. The stimulation of the restricted regions in the muscle of the base of rabbit ear, which was reported as an acupuncture point, caused evoked potential in the d-PAG, identified as an acupuncture pathway in previous studies. However, stimulation beyond this region or stimulation of another muscle, which was reported to be a non-acupuncture point, did not cause such evoked potential. The diameter of these limited regions able to cause evoked potential, estimated as an acupuncture point, was about 6 mm. Therefore, the so called " acupuncture point " is not a point, but rather, a region. Stimulus strength which causes moderate muscle contraction was necessary to cause evoked potential in the d-PAG by stimulation of acupuncture region. The stimulation of the muscle nerve found in the acupuncture region caused evoked potential quite similar to that caused by acupuncture stimulation. Another evoked potential with long latency was induced by intense noxious stimulation of acupuncture regions. This kind of evoked potential was abolished by cutaneous application of local anesthetics, i, e. procaine, without affecting evoked potential with short latency, and was not induced by muscle nerve stimulation in the acupuncture region. Evoked potentials with shorter latency than those of the dorsal region of PAG were recorded from the lateral PAG region of the periaqueduct level by stimulation of the acupuncture region. The latent periods of lateral PAG and dorsal PAG evoked potentials were 14.7±3.1 msec (n=3) and 21.2±3.5 msec (n=10) in rabbit, 6.0±0 msec (n=4) and 11.6 +3.0 msec (n=5) in rats, respectively. It was found in previous studies in our laboratory that the acupuncture afferent pathway was divided into 2 parts, one (R<SUB>1</SUB>) is inhibited by the inhibitory system and the other (R<SUB>2</SUB>) is not inhibited and that the lateral PAG belonged to R<SUB>1</SUB>, and the dorsal PAG to R<SUB>2</SUB>. These 2 pathways were confirmed in the present experiment by differentiation of regions and of latent period in evoked potentials. Evoked potential of the anterior hypothalamus, which had been identified as a R<SUB>1</SUB> pathway, showed shorter latency, while those of the dorsal hippocampus, habenula nucleus, medial centromedian nucleus of the thalamus and anterior bypothalarrus, which had been identified as R<SUB>2</SUB> pathways, exhibited long latency. Two acupuncture afferent pathways were confirmed by latency of evoked potentials in the present experiment.
- 学校法人 昭和大学・昭和医学会の論文