Thymoxamineの肝に及ぼす影響-2-肝薬物代謝酵素に及ぼす影響について
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概要
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The effects of thymoxamine (Mox) as an α-adrenergic blocking agent and its metabolites, deacetyl-thymoxamine (DAM) and deacetyl-demethyl-thymoxamine (Met-X), on the drug-metabolizing enzyme in rats were investigated and were compared to those of the other α-blocking agent, ifenprodil (Ifen) .<BR>The Mox-treated (150 mg/kg, p.o./day for 4 days) group showed a slight increase in aminopyrine demethylase activity, cytochrome b<SUB>5</SUB> and cytochrome P-450 contents.<BR>The Ifen-treated (50 mg/kg, p.o./day for 4 days) group showed a tendency towards increase of cytochrome b<SUB>5</SUB> and cytochrome P-450 contents.<BR>Microsomal lipid peroxide formation was inhibited by the administration of Met-X (150 mg/kg, p.o./day for 4 days) .<BR>Aminopyrine demethylase activities and cytochrome P-450 contents were significantly decreased by the administration of CCl<SUB>4</SUB> (0.5 ml/kg, s.c./day for 4 days) .<BR>Microsomal lipid peroxide formation induced by CCl<SUB>4</SUB> was inhibited by the administration of Mox, DAM and Met-X (150 mg/kg, p.o./day for 4 days) . This inhibitory potency was Met-X>DAM>Mox.<BR>From the fact that Mox showed a slight induction of mirosomal drug-metabolizing enzyme, in rats, it seems that this is an adaptive reaction of the liver due to the administration of Mox.
- 昭和大学・昭和医学会の論文