ニトロプルシッド,トリメタファン低血圧麻酔が糖代謝におよぼす影響

概要

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This study, carried out using mongrel dogs in which we induced hypotension by S. N. P. and T. M. P., represents our efforts to measure the carbohydrate metabolism, acidbase balance and hemodynamics during a hypotensive situation. During hypotension, mean arterial pressure ranged from 50 to 60 percent of pre-examined levels. The results are as follows: 1) T. P. R. decreased significantly during hypotension in S. N. P. group. In T. M. P., both T. P. R. and C. O. decreased significantly. 2) A significant increase of blood glucose was found in S. N. P. group, but not in T. M. P. group. 3) Lactate, L/P ratio and excess lactate increased significantly in S. N. P. group, but not in T.M. P. group. 4) In both groups, PvO2 tended to increase, but the decrease of A-vCDO2 and VO2 was not seen. From the above results, it was suggested that the hypotensive action of S. N. P. was mostly due to the decrease of T. P. R., and that of T. M. P. was due to the decrease of both T. P. R. and C. O., furthermore, S. N. P. tended to lead tissue to hypoxia more markedly than T. M. P.. It can be concluded that induced hypotension by S. N. P. tends to cause metabolic acidosis due to the anaerobic metabolism brought by the deterioration of peripheral circulation or cyanide poisoning. In adaition, on T. M. P, has a tendency to maintain peripheral circulation comparatively well.
学校法人昭和大学・昭和医学会の論文