Adenosine triphosphateの循環系に対する基礎的研究--家兎大動脈摘出標本に対するadenosine triphosphateの効果
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概要
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Extracellural administration of adenosine triphosphate has been known as potent vasodilator and has been used for the treatment of hemorrhagic shock or intentional hypotensive anesthesia.<BR>But the mechanism of its action on vascular smooth muscle has not been studied sufficiently yet.<BR>On the isolated spiral-cut aortic strip of the rabbit, adenosine triphosphate showed inhihitory action on the phenylephrine dose-response curve of the strip dose-dependently.<BR>The aortic strips, brought to the half-maximal contracted state by phenylephrine or histamine were relaxed by adenosine triphosphate as the same manner as lidocaine and quite different from those of phenoxybenzamine, diphenhydramine and isoproterenol.<BR>These findings suggested that adenosine triphosphate may act as a non-specific vasodilator on the vascular smooth muscle.
- 昭和大学・昭和医学会の論文