吸入麻酔薬(笑気,ハロセン,エ-テル)視床下部視索上核(SON)のユニット活動に及ぼす影響

概要

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Neurosecretory neurons were identified in the rat supraoptic nucleus (SON) by the antidromic response to stimulation of the neurohypophysis. I investigated the effects of inhalation anesthetics (nitrous oxide, halothane, diethyl ether) on the unit activity of antidromically identified neurohypophysial neurosecretory neurons. As inhalation of anesthetic agents, 67% nitrous oxide-oxygen (GO), 0.3%-0.5% halothane-oxygen (OF), 0.3%-0.5% halothane-67% nitrous oxide-oxygen (GOF), 6%-12% diethyl ether-oxygen (OE), 6%-12% diethyl ether-67% nitrous oxide-oxygen (GOE) were studied in 5 identified units respectively.<BR>Inhalation of GO showed no change in spontaneous firing rate of the units. OF and GOF showed variant changes of the unit activity.<BR>As the case of OE and GOE, 4 out of 5 tested units exhibited inhibition of the unit firing after inhalation respectively.<BR>From these results, it was concluded that the most of neurohypophysial neurosecretory neurons of the rat supraoptic area were inhibited by inhalation of diethyl ether.
昭和大学・昭和医学会の論文