膵癌の臨床病理解剖学的ならびに実験的膵癌の病理組織学的電顕的研究

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The 38 autopsy cases of primary carcinoma of the pancreas, containing 9 cases performed Pancreozymin-Secretin Test (P-S test) were studied pathologically in order to make clear relation between the values of P-S test and morphology of pancreatic carcinoma. Experimental carcinogenesis of the pancreas were attempted in rats after the implantation of 7, 12-dimethylbenz (a) anthracene (DMBA) to examine histogenesis of carcinoma.<BR>The 67 per cent of pancratic carcinoma performed P-S test revealed abnormal values : A decreased tendency of each parameter of P-S test was apt to be shown in cases of diffuse invasion to the pancreas and with much stroma of carcinoma. The volume of pancreatic juice was not often influenced by carcinoma. And no significant relation was showed between occupational region of carcinoma and extent of decrease values of P-S test.<BR>The 24 per cent of 29 rats induced malignant tumor of the pancreas ; 5 well different adenocarcinomas, one spindle cell sarcoma and mixed tumor of adenocarcinoma and spindle cell sarcoma. Spindle cell sarcoma was thought myosarcoma after light and electron microscopical examination. Adenomatous hyperplasia was observed in all cases except one.
学校法人昭和大学・昭和医学会の論文