免疫グロブリンの実験的研究--Prednisolone,6-Mercaptopurineの家兎免疫グロブリン(IgG,IgM)に及ぼす影響について
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IgG, IgM, anti-BSA-IgG and anti-BSA-IgM were measured by the immunodifusion technique. Serum titers of antibody as a whole was measured by the hemagglutination technique.<BR>(1) Primary response: Prednisolone or 6-MP was administered simultaneously with the 1st immunization of BSA. The quantity of IgG was also lower in both of the 6-MP and prednisolone groups compared with the control group, and its reduction was larger in the 6-MP group than the prednisolone group. There were no differenced in IgM among the three groups. The hemagglutination titers were lower in both groups compared with the control group. The grade of reduction was larger in 6-MP group.<BR>(2) Secondary response. In this case also prednisolone or 6-MP administered simultaneously with the 2nd immunization of BSA. There were no differenced in the hemagglutination among three groups. No change of serum IgG was observed in the prednisolone group, but it was slightly lower in the 6-MP group. IgM showed a similar tendency with IgG in the three groups.<BR>(3) The effects of continuous administration of the drugs on the 2nd immunization were examined. IgG gradually decreased by the administration of prednisolone, and showed a tendency of increase by its discontinuance. In the 6-MP treated group, it slightly decreased. IgM also decreased in both of the prednisolone and 6-MP groups. Anti-BSA-IgG increased slightly 7 to 12 days after the immunization and was kept at the same level in the control group. In the prednisolone group, anti-BSA-IgG slightly decreased, while it decreased markedly in the 6-MP group.
- 学校法人 昭和大学・昭和医学会の論文