γ-Glutamyltransferaseに関する研究-2-臨床的研究急性ウイルス性肝炎におけるγ-Glutamyltransferaseの動態と予後

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2. Clinical study ; Correlation between change of γ-Glutamyltransferase activity and prognosis in acute viral hepatitis In 119 cases of acute viral hepatitis (AVH), which were classified into 6 types according to clinical and histo-pathological criteria, serum γ-Glutamyltransferase (s-γ-GT) was assayed in comparison with other hepatic enzymes and was estimated in prognosis of this disease. Level of s-γ-GT did not reflect hepatocellular injury, but moderately elevated at the crisis of the disease and delayed recovery to normal level. The change of s-γ-GT level was not always paralleled with that of s-alkaline phosphatase, s-Leucine aminopeptidase and s-Bilirubin in AVH. The γ-GT/GPT ratio was thought to be the most useful indicator to evaluate clinical type, stage and severity in AVH. Estimation of the clinical course in AVH could be obtained from the correlation between γ-GT and transaminase in early stage, although the γ-GT/GPT ratio never indicated the tendency to chronicity or fibrosis. However, no elevation of γ-GT could be found even if liver parenchymal damage was fatal. The dissociation between s-γ-GT and s-Bil, was considered the severe sign in prognosis of this disease. Determination of γ-GT activity and the γ-GT/TA ratio was extremely valuable to differentiate acute alcoholic hepatitis from AVH, but it was not useful in acute exacerbation of chronic liver disorders.
学校法人昭和大学・昭和医学会の論文