実験的胃潰瘍に対するL-Carnosine(N-2-M)の効果

概要

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Since L-carnosine exerts a facilitating action on experimental formation of granulation tissue, the effect of L-carnosine on various kinds of experimental gastric ulcer was studied ; and the following conclusions were obtained : 1) A slight preventive effect was noted in the development of acute experimental gastric ulcer, but scarcely any therapeutic effects were found. 2) In cortisone-induced ulcer, combined administration of L-carnosine definitely exerted a preventive effect. 3) In clamping cortisone ulcer and acetic acid ulcer which are experimental ulcers considered to closely resemble chronic gastric ulcer in man, subcutaneous administration of 200-500 mg/kg of L-carnosine markedly facilitated healing. 4) L-carnosine administration completely inhibited the decrease of blood flow through the gastric mucosa seen in gastric hypermotility. 5) L-carnosine administration induced early formation of new blood vessels in the healing process of acetic acid ulcer. 6) L-carnosine failed to influence gastric secretion from the Heidenhein pouch.
学校法人昭和大学・昭和医学会の論文