小児期における免疫グロブリンの消長に関する研究

概要

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Studies were performed on immunogloblin (Ig) in the childhood of both healthy and disease status utilizing immunoplate technic, and following results were obtained.<BR>1. The level of IgG in healthy children decreased after delivery down to 35% of adults value at the age of 7-9 months followed by elevation gradually thereafter, and reached to 80% of them at 6 years of age. Similar tendency was observed in the distribution of IgA as of IgG, while IgM increased rapidly and reached to almost same level as those of adults at the 6 years.<BR>2. Decreassed IgG were observed in nephrotic syndrome with nonspecific change both in IgA and M. Howevrer, no remarkable change of IgG, A and M were seen in the stage of remission.<BR>3. In collagen disease, especially in SLE, moderately elevated value of IgG were observed in the initial stage, and returned to normal at the time remission. No remarkable change are seen in the both IgA and IgM.<BR>4. Both IgG and A showed elevated level at the time of diagnosis in leukemic children, while IgM showed elevation in the two third of the cases. Upon starting antileukemic treatment, all the classes of Ig tend to decrease. However, the level of IgG keep continuing alomost same value in the long-surviving cases till the deteriorating stage in hematological conditions preior to expiration.
学校法人昭和大学・昭和医学会の論文