Ethyladrianol,Butylsympatol,Metaproterenolの2〜3動物の非妊および妊娠子宮に対する作用

概要

論文の詳細を見る
Effects of ethyladrianol, butylsympatol and metaproterenol on isolated uterus in pregnant and nonpregnant rabbit, rat, guinea-pig and mouse were investigated.<BR>The results obtained were as follows :<BR>1) By the administration of ethyladrianol at all doses tested, uterine motility in nonpregnant guinea-pig or rabbit was stimulated. On the other hand, ethyladrianol at all doses caused inhibition of uterine motility and contractile activity in uterine smooth muscle in pregnant rabbit and guinea-pig, except at lower dose uterine motility in pregnant rabbit was stimulated. It caused inhibition of uterine motility in pregnant and nonpregnant rat and mouse, regardless of its doses used.<BR>2) Butylsympatol and metaproterenol caused inhibition of uterine motility in pregnant and nonpregnant rabbit, mouse and rat regardless of its doses used. They caused stimulation of uterine motility in nonpregnant guinea-pig at all dose tested, except higher doses tested showed marked inhibition of uterine motility in pregnant guinea-pig. Therefore, adrenergic β-receptor stimulanting agents generally showed inhibitory effects on uterine smooth muscle.<BR>3) The sensitivity of three adrenaline derivatives tested to pregnant uterine motility is 10 times as higher than that to nonpregnant case.
学校法人昭和大学・昭和医学会の論文