実験的肝炎--ヒト伝染性肝炎患者胆汁接種による実験的家兎肝炎
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概要
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A fulminant hepatitis was experimentally induced in 5 out of 20 rabbits by inoculation with duodenal juice, obtained from patients with infectious hepatitis, by the combination of daily injections of steroid hormone and insulin.<BR>Histologic findings were characterized by multifocal liver necrosis surrounding by infiltration of a great number of polymorphonuclear lemocytes and mononucler cells. These findings were observed during the period between 5 and 12 days after injection of duodenal juice. The pathological findings were closely similar to acute yellow atrophy of the liver of human.<BR>Rabbits, used as a control, which were injected only steroid-hormones and insulin showed no abnormality by the light microscopy.<BR>Laboratory test, including S-GOT and S-GPT, showed no significant difference between experiment and control animals, although S-GOT of a rabbit rised slightly after injection of duodenal juice.<BR>Immunolo-fluorescent study, using F.I.T.C. (Fluorescein isothiocyanate) labeled rabbit antibody against Australian antigen, showed no specific staining in the liver tissue at all.
- 昭和大学・昭和医学会の論文