薬物投与によって誘発されたネコ脊髄のsynchronized waveについて

概要

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From the spinal cord, one can lead off the electrical activity which is characterized as low frequency and low amplitude varying potentials. We call these potentials as the Spinal Electrogram. A synchronization of these electrical activities was evoked by the injection of drugs such as. tubocurarine and succinylcholine. The synchronized wave has a high amplitude (100-120μV) and low frequency (5-9c/s) . The duration of the wave was between four and eight seconds. Hypoxia also produced a synchronization of SEG. The synchronization of SEG occured spontaneously by the administration of tubocurarine chloride (2 mg/kg) and succinylcholine (0.6 mg/kg) and also frequently evoked by the stimulation of dorsal root under these drugs. The synchronized SEG was recorded from the relative broad areas, 2 to 3 segments, in the spinal cord. The dorsal root stimulation modified the rhythm. The disruption, resetting and termination of the rhythm were obserbed. It is concluded that the synchronization of SEG might be related with the internuncialneuron's activity which was enhanced by drugs.
学校法人昭和大学・昭和医学会の論文