亜硝酸ソーダによる心臓の低酸素症病変について
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概要
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1 A histopathological study was conducted on lesions in rabbit heart upon parenteral administration of sodium nitrite known to be toxic through methemoglobin formation daily in doses of 40, 60 and 80 mg/kg for a short and long period.<BR>2. The fundamental changes consisted of disturbance in blood circulation, congestion (or hyperemia), causing degenerative changes of the parenchymal cells of the myocardium as the manifestation of hypoxia. However, these changes mainly consisted of granular degeneration, destruction and dissolution of myocardial fibers and seldom underwent necrosis, fibrosis and cicatrization, although scattered areas of round cell infiltration may be seen at the far advanced stage.<BR>3. Changes in blood vessels especially arteries simultaneously or slightly earlier than the changes above mentioned are characteristic. Arterial walls show vacuolization, porotic changes, and partial degeneration and atrophy. As the time factor sets in, PAS positive substance appears in the wall of small arteries and veins, infiltrating around the blood vessel and into the interstitial tissue between muscle fibers and showing imbibition of muscle fibers. Proliferation of fibers and a tendency of cicatrization is seen in this location.<BR>4. The lesions were more severe in long term administration than in short term administration, upon the use of a large amount than a small amount, and in left ventricular muscle, septal muscle, and right ventricular muscle in the increasing order.<BR>5. Concerning the process of myocardial cicatrization, it seemed to be of primary importance that hydrops-like sclerosis due to lesions in the blood vessel spreaded to interstitial tissue and parenchyma rather than that the injury to parenchymatous cells led to fibrosis.
- 学校法人 昭和大学・昭和医学会の論文