Phenylhydrazine処理家兎における溶血態度,血清蛋白の変動およびErythropoietin産生能に関する研究
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概要
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Studies were performed on the pattern of hemolysis and change of fraction of serum protein with the production of erythropoietin in the phenylhydrazine-treated rabbits, and following results were obtained.<BR>1. Hemoglobin concentrations, hematcrit and erythrocyte count showed marked decrease after starting the daily injection of phenylhydrazine and reached to the half level in their value by the fifth day.<BR>Reticulocyte count increased abruptly few days after starting injection.<BR>2. Decrease of albumin and increase of α<SUB>2-</SUB> and γ-globulin were seen as the degree of anemia enforced.<BR>3. Efforts were done for obtaining different level of hemoglobin concentration upon exanguination. Increased erythropoietin titer was obtained in 85.7 % of specimens with below 6.5 Gm/dl of hemoglobin concentration. However, elevated erythropoietin was seen in few subjects with those of over 6.5 Gm/dl of hemoglobin.
- 学校法人 昭和大学・昭和医学会の論文