Penicillin誘導体の研究-1・2-
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概要
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1) Antibacterial activity of 21 kinds of penicillin derivatives was tested against 18 kinds of bacterium. It was found that their activity fairly varied according to the kinds of bases used.<BR>P-aminobenzaldehydethiosemicarbazone-Pc and dl-p-nitrophenyl-2-amino-1, 3-propanediol-Pc showed high antibacterial activity against gramnegative bacteria which had low sensitivity to penicillin and p-aminobenzaldehdethiosemicarbazone-Pc and p-aminosalicylicacid-Pc showed rather high antibacterial power against Myco. tuberculosis H 37 RV that was not so sensitive to penicillin.<BR>2) Various kinds of salts obtained by making various organic bases react to penicillin showed the same grade of activity as procain-Pc against grampositive cocci sensitive to penicillin.<BR>3) Pyrimidine-Pc showed much higher antibacterial activity than procain-Pc against Br. melitensis.<BR>4) It was studied how the drug resistance of Staph. aureus 209 P and Terashima to various penicillin derivatives would develop. It was found that Staph. aureus 209 P and Terashima got resistance against metal (Na and Ca) salts of penicillin as well as against its organic salts. They got resistance more easily against the former.<BR>Penicillin resistant variants of bacterium were likely to show rather poor growth in the culture media.
- 昭和大学・昭和医学会の論文