線維素溶解現象とアスコルビン酸
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概要
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Some cases of blood diseases are accompanied by the bleeding tendency. One of the causes of bleeding is considered to be due to fibrinolysis.<BR>Fibrinolysis is demonstrated in the patients blood of blood diseases, brain hemorrhage, nephritis, malignant tumor and allergic diseases and also in a certain condition of a normal individual.<BR>Fibrinolytic activity was measured by the use of Astrup's fibrin plate methd in patients received daily administration of ascorbic acid, and the following results were obtained.<BR>1) Fibrinolytic activity was, as a rule, low in the blood of normal individuals.<BR>2) The highest fibrinolytic activity were remarked in hemopathy. One case of chloroma showed strong fibrinolytic activity even in blood plasma.<BR>3) When 100-400mg per day of ascorbic acid was administered, no inhibition was effected, while, when 500-1000mg per day was given continuously, inhibitory effect was seen on the seventh day. This effect was most significantly seen in nephropathy, while it was not marked in other diseases.<BR>4) Activator in urine was of low value in any of the diseases, and was not changed even after administration of ascorbic acid.<BR>5) Ascorbic acid produced no inhibitory effect on fibrinolysis in vitro.<BR>6) Administration of 1000 mg per day of ascorbic acid produced ont only inhibition of fibrinolysis in blood and increase of fibrinogen, but also such clinically observed improvements as increase of urine and disappearance of urinary albumin in sone cases of nephritis.<BR>7) The mechanism of inhibitory action of ascorbic acid on fibrinolysis is still obscure.
- 学校法人 昭和大学・昭和医学会の論文