被照射腫瘍細胞の核分裂とサイミヂンとりこみについて

概要

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Experimental studies on mitotic behaviors and labeled thymidine uptake in respect to DNA synthesis were carried out by irradiated Yoshida ascites tumor transplanted in Donryu rats.<BR>Decreasing pattern in mitotic index was found to be the proof that time required to complete the mitosis was not altered by 1000 R irradiation.<BR>Prophase, metaphase, anaphase, and telophase seemed to proceed in their normal speed regardless of the irradiation. These processes were analysed by disintegration formula of radon to find good fitfulness though the mechanisms were to be considered otherwise.<BR>The labeled cells made their appearance earlier than mitosis indicating the DNA synthetic phase prior to mitosis. It was noted that irradiated cells incorpprated more thymidine than not irradiated cells, though precise studies were left to be done. However, these findings were to be the proof indicating the decrease of de novo thymidine synthesis in irradiated tumor cells which incorporated more thymidine by salvage path way than not irradiated cells.
学校法人昭和大学・昭和医学会の論文