人胎盤絨毛組織のコハク酸脱水素酵素に関する研究
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概要
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1) The activity of SDH in normal human placental chorionic villi began to increase from the initial period of pregnancy, reaching the maximum level at the 4th month of pregnancy. Then the activity showed a sharp decrease and increased at the 7th month of pregnancy again. However, since then the activity of this enzyme again gradually decreased indicating the minimal value at the 40th week of pregnancy. The placenta in the overterm showed a decreasing tendency in the enzymatic activity which more decreased after the 43rd week. There was a negative relationship between the duration of pregnancy and the degree of decrement in the activity.<BR>2) In general, the activity of SDH in the placenta of late toxemic pregnancy was lower than that of placenta in normal delivery. The decrease in the activity was more striking with more severe case of toxemic symptoms. The enzymatic activity in the premature spearation of the normally inplanted placenta revealed a prominent low value.<BR>3) The value of enzymatic activity of placenta in the stage before beg-ing of pain was found to be somewhat greater than that of the stage starting in labor.<BR>4) The enzymatic activity in the placenta with intra-uterine fetal death was extremely low.<BR>5) As observed in vitro, L-aspartic acid and L-ornithin, L-aspartate brought no effects against this activity of human placental chorionic villi in the early stage of pregnancy. However, the placentas of normal pregnant women at the 10th month which were given with these drugs orally revealed remarkably higher activities than thcse of controls without these drugs.