造血因子Caeruloplasminに関する研究

概要

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Using a devised method of quantitative determination by Ravin's method, serum caeruloplasmin level was determined on rabbits rendered anemic by bleeding or by hemolysis anemia due to the administration of phenylhydrazine, and also on the hypoxic rabbits. The value of serum copper was detertmined for the investigation of its relalion to caeruloplasmin. The results obtained were as follows. 1. In the plasma of rabbits rendered anemic by bleeding, both serum copper and caeruloplasmin increased accompanying the appearance of anemia. 2. In the rabbits rendered anemic by phenydrazine hemolysis, both serum copper and caeruloplasmin increased remarkably following the development of anemia. 5. In the rabbits under hypoxic conditions, erythrocytes hemoglobin content, and reticulocytes increased but there was some discrepancy in the value between serum copper and caeruloplasmin depending on the length of the time placed under hypoxic conditions. a. In the rabbits placed under hypoxic conditions for 3 hours, both serum copper and caeruloplasmin were reduced. b. In those placed for 24 hours, both serum copper and caeruloplasmin values were also reduced. c. In those placed for 48 hours, serum copper showed a remarkable increase, whereas, caeruloplasmin was reduced.
学校法人昭和大学・昭和医学会の論文