Isonicotinyl hydrazide及びSodium Glucuronate isonicotinyl hydrazoneの鶏胎仔Glutathione代謝に及ぼす影響

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Embryonating eggs received the injection of isonicotinyl hydrazide (INAH) and sodium glucuronate isonicotinyl hydrazone (INHG-Na) and the content of reduced glutathione (GSH) was determined on the eye ball, brain, liver and the muscle of the developing embryos for the comparison of the tissue GSH content between the administration of INAH and INHG-Na. Results obtained were as follows:<BR>1. GSH content of the eye ball showed a tendency of moderate increase by the administration of INAH. Administration of INHG-Na showed no remarkable difference.<BR>2. GSH content of the brain showed a tendency of slight increase toward the latter half of the incubation period by the administration of INAH. But the increase which followed the administration of INHG-Na was smaller.<BR>3. GSH content of the liver and muscles showed an increase by the administration of INAH. But the administration of INHG-Na showed no remarkable influence.<BR>In short, both the administration of INAH and INHG-Na showed some influence on the glutathione metabolism of chick embryos but the influence of more toxic INAH was stronger than that of INHG-Na.
学校法人昭和大学・昭和医学会の論文