Chlorpromazineの動物雌性生殖機能に及ぼす実験的研究
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概要
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Stated in the following are the conclusions drawn from the studies of the influence of Chlorpromazine on the reproductive functions of female animals :<BR>1. Sexual cycle of rats was inhibited by Chlorpromazin and this inhibitory influence parallelled the dose administered. Sexual cycle was restored to normal upon suspending the administration.<BR>2. On mice, the administration of Chlorpromazine during pregnancy scarcely influenced the period of pregnancy and the embryos received little influence, the time of delivery being normal in most cases.<BR>3. Reproductive ability of Chlorpromazine pretreated mice was found to be lowered and the period from mating to the delivery was prolonged. The size of a litter was smaller but the weight of individual suckling was comparable to that of the control. No appreciable difference from the control was observable in the growth of the litter.<BR>4. Ovulation of rabbit by the injection of CuSO<SUB>4</SUB> 5 mg by two injection method was inhibited by the administration of Chlorpromazine in a dose over 10.4 mg/kg.<BR>5. Pretreatment with Chlorpromazine in a dose of 35-175 mg failed to inhibit the ovulation of rabbit elicited by the administration of Gonadotropin.<BR>6. In either case of in vivo or in vitro experiment, Chlorpromazine lowered the O<SUB>2</SUB> consumption of the rabbit diencephalon. In vitro, this lowering in O<SUB>2</SUB> consumption was especially strong in the posterior part of the diencephalon. It was rare, however, to lower the O<SUB>2</SUB> consumption of cerebral cortex, cerebellum, hypophysial anterior lobe and the ovary.<BR>In view of the findings of experiments stated above, it was concluded that Chlorpromazine inhibits the functions of diencephalon, especially hypothalamus, disturbs the functions of the diencephalon-hypopheseal anterior lobe-sexual gland system inviting the lowering of the reproductive functions of female animals.
- 学校法人 昭和大学・昭和医学会の論文