Nicotine tartrateの鶏胎仔Glutathione代謝に及ぼす影響

概要

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Investigations were made on the influence of Nicotine tartrate (NT) injection on the Gluta-thione concentration (mostly, reduced Glutathione -GSH-) of the developing chick embryos. Stated in the following are the results obtained thereof:<BR>GSH concentration of the brain showed practically no difference by the administration of NT, while that of the liver showed an evident increase as far rs the 15th day of incubation.<BR>GSH concentration of the eye ball showed a remarkable lowering by the administration of NT, while that of the muscles showed a high concentration on the 9th day of incubation.<BR>Changes in the GSH concentration of the yolk were stronger following the increase in the amount of NT administered and the mode of those changes was highly complicated.<BR>In short, the administration of NT causes the development of marked growth disturbance, especially, malformation and hydrops, and it was found that this growth disturbance is always accompanied by the anomaly of glutathione metabolism. On the other hand, it appears that this toxic effect of NT is weaker but lasts for a longer period than Nicotine.
学校法人昭和大学・昭和医学会の論文