Cholera vibrioのpenicillin抵抗に関する研究

概要

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The effect of penicillin on the Cholera vibrio was studied and the following results were obtained. 1. Cholera vibrio is originally resistant to penecillin and the minimum inhibitory dose ranges from 1 to 32 u/ml. The resistance was increased by successive inoculation in the penicillin-containing media. 2. The biological activities of strains on increased resistance were slightly decreased or not changed, as compared with original strains. 3. The catalase activities were increased in the early stage of penicillin action, and became normal after 10th passage in penicillin-containing media. 4. The resistance of Cholera vibrio was decreased to the original level when preserved in the broth. 5. No special difference was seemed to be present in the mode of resistance increase between penicillin-sensitive staphylococcus and resistant vibrio.
学校法人昭和大学・昭和医学会の論文