Isonicotinic Acid Hydrazide及びPyrazinamide投与と生体内ニコチン酸代謝について

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概要

• 論文の詳細を見る

• As a step for the clarification of the mechanisms of the development of B group vitamin deficiency encountered while undergoing chemotherapy, especially, antibiotic treatment, investigations were made on the influence of anti-tuberculous drugs (INAH, PZA, SM and PAS) on the in vivo nicotinic acid metabolism.<BR>Previously, Zatman et al suspected the occurrence of competitive inhibition by INAH on the basis of its resemblance to nicotinic acid in chemical structure and proved this on animal experiments. This author also proved this competitive inhibition of nicotinic acid metabolism on clinical cases.

• 昭和大学・昭和医学会の論文

著者

• 野口 英世

  昭和医科大学第一内科学教室

関連論文

• Isonicotinic Acid Hydrazide及びPyrazinamide投与と生体内ニコチン酸代謝について

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