2-Acetylaminofluorene投与白鼠肝の病理組織学的変化,特に嚢腫生成に関する研究

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概要

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• The early pathological and histological changes in liver of wistar rats fed with 0.03% 2-acetylaminofluorene (2-A.A.F.) were studied. A few observations were made on the cystoadenomatous formation and on the relation between liver cells and epithelial cells in the bile duct.<BR>1) The small clear cells (epithelial cells originated from small bile duct) were found around the portal area at the 7th day following the administration. The dendric proliferation of these cells was seen in the space of liver cell trabeculae with the elapse of time. It was found that the periphery of the liver lobules was surrounded by small clear cells and the psudo-annular cirrhosis in liver after one month following the adminstration. At this stage some of the small clear cells have changed into cystoadenoma.<BR>2) The mode of development of cystoadenoma was as follows. The stagnation of the secret was occurred, as the result of stenosis in the lumen of ductlike structure of small clear cells, thus the cystic dilatation was revealed as cystoadenoma.<BR>The size and form of cystoadenoma are rich in variety. The form of epithelial cells lining the cyst was flat, cuboidal, cylindrical and so on.<BR>3) On the 31st day following the administration marked progressive or hyperplastic changes of the liver cells were observed. This change indicates the nodular hyperpaasia.<BR>4) These small clear cells were stained differently from the liver cells or the epithelial cells in the bile duct by PAS-methylgreen staining. The cytoplasm of non-progressive liver cells contained PAS-positive large granules abundantly. PAS-positive granules in the progressive liver cells were small and scatteredly (prominent decrease in the number of granules) . The transformation and decrease in the number of mitochondriae were found remarkably by Heidenhain's iron haematoxylin and Altmann's stain. PAS-positive granules were not found in the cytoplasm of epithelial cells in the small clear cell. The nuclei and cell membrane of these cells were stained green with methylgreen. The granules of mitochondria did not noticed with Heidenhain's iron haematoxylin and Altmann's stain.

• 学校法人 昭和大学・昭和医学会の論文

著者

• 佐川 文明

  昭和医科大学第二病理学教室

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• 2-Acetylaminofluorene投与白鼠肝の病理組織学的変化,特に嚢腫生成に関する研究

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