p-aminoanthrachinonの継続投与による白鼠腎の病変について
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概要
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It has been noticed that by long period (about 3 months) oral administration of p-aminoanthrachinon, kidneys of rats showed remarkable atrophic sclerotic lesions. In order to analyse the histological process of these changes, 0.01g (early stage) -0.27g (later stages) of p-aminoanthrachion were administered orally (rats were fed with p-aminoanthrachinon for 4-40 days) and kidneys were examined histologically.<BR>In the early stages, yellowish needle-shaped crystals blockade some proximal convolution, thick limbs of Henle's loops and collecting tubules. As time went by, many crystals obstructed mainly the proximal convolution and the tubular epithelium near the casts of the crystals were partly lost, partly flattered or detached from the basement membrane. The granulation were formed with the foreign body giant cells around the obstructed crystals and the destruction of the nephrons with casts and compensative enlargement of remaining nephrons occurred. The gromeruli swelled up in the middle stage and later showed thickening, hyalization and atrophy of the capillary sling. The interstitial fibrosis and cell infiltration increased gradually from the middle stage.
- 昭和大学・昭和医学会の論文