端板電位に対するAcetylcholineならびにEserineの影響

概要

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In the present work, the authors recorded the end-plate potential by Ozawa's separa-tion method employing the sartorius muscle of Bufo vulgaris. The muscle was curarized before the experiments. When acetylcholine was applied, the end-plate potential gradually rose as the time elapsed at the concentration approximately 10-8. With acetylcholine solution at the concentration approximately 10-2, the end-plate potential gradually diminished. At the concentration of 10-3 or 10-4, the end-plate potential was inhibited in the beginning and facilitated later. Approximately the same trend in the action of eserine on the end-plate potential was noted. When the end-plate potential of curarized muscle was raised to certain degree by the action of acetylcholine or of eserine, the nerve impuls was transf eyed to muscle, and the muscle contraction was induced.
昭和大学・昭和医学会の論文