Nicotine並にPyridine誘導体の鶏胎仔副腎アドレナリン量に及ぼす影響に就て

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As a part of the series of pharmacological studies on the embryonal stage, which are being carried on for many years in the author's Department, the author re-examined the adrenaline content of the adrenal glands of the normally developing chick embryo in the first place, and examined the influences of nicotine and pyridine derivatives on the general development and the adrenaline content of the adrenal glands of the chick embryo in the second place, attempting to study the actions of nicotine on the animals in the ernbryonal stage. On this occasion, pathological histological examinations were simultaneously conducted.<BR>The presence of adrenaline in the adrenal glands of the chick embryo in the normal development is clearly proved since 12 days after the hatching, and the content is found further increased on the 15 th and 18 th days from the hatching. The addition of nicotine (or nicotine tartrate) to the developing egg even further increases the adrenaline content in the adrenal glands compared with that in the corresponding stage of the normal development. However, pyridine or pyridine derivatives (INAH, nicotinic acid, nicotinamide and coramine) do not possess as much action in the same line as nicotine possesses, or they exercise almost no influence on the adrenaline content in the adrenal gland.
昭和大学・昭和医学会の論文